Models of the urinary concentrating mechanism
نویسندگان
چکیده
منابع مشابه
The urinary concentrating mechanism: a model of integrative physiology.
One of the most efficient water conservation mechanisms in mammals is the ability of the kidneys to produce concentrated urine for the elimination of waste products while losing a minimum of water. Depending on the food supply of differing animals, components of the glomerular ultrafiltrate are concentrated in the final urine to different extents. For example, carnivorous animals preferentially...
متن کاملMouse models and the urinary concentrating mechanism in the new millennium.
Our understanding of urinary concentrating and diluting mechanisms at the end of the 20th century was based largely on data from renal micropuncture studies, isolated perfused tubule studies, tissue analysis studies and anatomical studies, combined with mathematical modeling. Despite extensive data, several key questions remained to be answered. With the advent of the 21st century, a new approa...
متن کاملCarl W. Gottschalk's contributions to elucidating the urinary concentrating mechanism.
Like all of the participants in this symposium, I am very pleased to contribute to a scientific gathering that honors Carl W. Gottschalk—esteemed colleague, superb scientist, good friend, and admirable human being. Carl contributed importantly to our knowledge in several areas of renal function; today, however, I will limit myself to the topic in which he made perhaps his major contribution, na...
متن کاملThe effect of salt deprivation on the urinary concentrating mechanism in the dog.
According to the countercurrent theory (1-3), concentration of the urine results from the movement of water from the collecting tubule into the hypertonic medullary interstitium. Medullary hypertonicity is generated and maintained by the sodium transported out of the ascending limb of the loop of Henle and trapped in the medulla by the vasa recta which form a countercurrent exchanger. Consequen...
متن کاملThe effect of urea infusion on the urinary concentrating mechanism in protein-depleted rats.
To explore the role of urea in the urinary concentrating mechanism, the contents of vasa recta, Henle's descending limbs and collecting ducts were sampled by micropuncture of the renal papilla before and after infusion of urea in 10 protein-depleted rats. Eight protein-depleted rats not given urea were similarly studied as a control group. After urea administration, osmolality and the concentra...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1987
ISSN: 0085-2538
DOI: 10.1038/ki.1987.47